[PDF] Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review | Semantic Scholar (2024)

The role of inflammation, in general, and CRP, in particular, in the pathogenesis of schizophrenia and its potential significance in diagnostic, therapeutic, and preventative approaches towards schizophrenia and psychosis is evaluated.

The level of serum IL-1β in the first-episode group was significantly higher than in the recurrence group, and there was no significant difference between the first-episode group and the recurrence group, while IL-16 levels were an independent variable of the onset of schizophrenia.

Although the underlying pathophysiological role of CRP and hsCRP is still elusive and the association betweenCRP and psychiatric disorders is inconsistent, CRP holds promise to become a psychiatric biomarker.

A strategy to construct an immune signature that may be helpful in selecting and monitoring participants in studies with immune modulating drugs and also applicable in regular clinical work is proposed.

There is evidence of only a weak association between blood-based immune markers and cognition in mood and psychotic disorders and significant publication and reporting biases were observed and most likely underlie the inflation of such associations in individual studies.

In this study, cannabis cessation raises inflammatory markers though improving clinical symptoms in patients with schizophrenia, and could in the future be a new target for treatment of psychiatric symptoms linked to inflammation.

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Whether there is a causal relationship between higher CRP levels and the development of SZ and aggravation of psychotic symptoms, or whether they are solely a marker of systemic low-grade inflammation in SZ, remains to be clarified.

The results support a growing body of literature that schizophrenia is associated with increased inflammation, and suggest that measurement of blood CRP levels may be germane to the clinical care of patients with schizophrenia and related disorders.

Measurement of serum inflammatory parameters in psychiatric patients may be beneficial in order to obtain a better assessment of their metabolic risk profile.

The findings indicate that signs of inflammation may serve as a state-dependent marker of cognitive dysfunctions in acute psychosis as well as other measures of psychopathology including psychosis symptoms, depression, or functioning.

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